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Comodo Antivirus is certainly one of the best free antivirus program available.
This is due mostly to their proprietary Defense+ technology that assumes an unknown file is a potential threat, making this free antivirus program almost 100% effective. Most other antivirus programs assume unknown files are safe and only concern themselves with files that have proven to be a problem.
Important: Comodo Antivirus provides constant virus protection, also called on-access or resident protection, for free. This means that Comodo Antivirus can completely replace antivirus software from companies like McAfee and Norton that charge for their software and for yearly access to updates.

Pros

• Provides on-access protection from viruses and other malware
• Virus definitions are regularly updated, in the background
• Does not attempt to install unrelated software
• Works with Windows 7, Vista, and XP
• 64-bit versions are also available

Cons

• Can only be used at home - no business use
• Does not include a "Game Mode" (silent detection)

Description

• Comodo Antivirus includes a full range of detection engines for viruses, spyware, rootkits, and other malware.
• Includes protection from "all" infection sources like email, games, IM, etc.
• Windows 7, Vista, and XP are all supported operating systems for Comodo Antivirus.
• 64-bit program versions are available for those using 64-bit Windows operating systems.
• Comodo Antivirus updates periodically to stay current with new threats.
• Includes Defense+ technology that doesn't assume anything is safe, yet doesn't bother you with needless warnings either.

Guide Review - Comodo Antivirus